Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury
Identifieur interne : 000672 ( Main/Exploration ); précédent : 000671; suivant : 000673Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury
Auteurs : Carla Claser [Singapour] ; Samantha Yee Teng Nguee [Singapour] ; Akhila Balachander [Singapour] ; Shanshan Wu Howland [Singapour] ; Etienne Becht [Singapour] ; Bavani Gunasegaran [Singapour] ; Siddesh V. Hartimath [Singapour] ; Audrey W. Q. Lee [Singapour] ; Jacqueline Theng Theng Ho [Singapour] ; Chee Bing Ong [Singapour] ; Evan W. Newell [Singapour] ; Julian Goggi [Singapour] ; Lai Guan Ng [Singapour] ; Laurent Renia [Singapour]Source :
- Nature Communications [ 2041-1723 ] ; 2019.
Abstract
Malaria-associated acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are life-threatening manifestations of severe malaria infections. The pathogenic mechanisms that lead to respiratory complications, such as vascular leakage, remain unclear. Here, we confirm that depleting CD8+T cells with anti-CD8β antibodies in C57BL/6 mice infected with
Url:
DOI: 10.1038/s41467-019-12017-8
PubMed: 31534124
PubMed Central: 6751193
Affiliations:
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Hartimath</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0393 4167</institution-id><institution-id institution-id-type="GRID">grid.452254.0</institution-id><institution>Isotopic Molecular Imaging Laboratory,</institution><institution>Singapore Bioimaging Consortium (SBIC), A*STAR,</institution></institution-wrap>11 Biopolis Way, #02-02 Helios, Singapore, 138667 Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>11 Biopolis Way, #02-02 Helios, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Audrey W Q" sort="Lee, Audrey W Q" uniqKey="Lee A" first="Audrey W. Q." last="Lee">Audrey W. Q. Lee</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0637 0221</institution-id><institution-id institution-id-type="GRID">grid.185448.4</institution-id><institution>Singapore Immunology Network (SIgN),</institution><institution>A*STAR, 8A Biomedical Grove,</institution></institution-wrap>Level 3 & 4 Immunos Building, Singapore, 138648 Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Level 3 & 4 Immunos Building, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Theng Theng Ho, Jacqueline" sort="Theng Theng Ho, Jacqueline" uniqKey="Theng Theng Ho J" first="Jacqueline" last="Theng Theng Ho">Jacqueline Theng Theng Ho</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0637 0221</institution-id><institution-id institution-id-type="GRID">grid.185448.4</institution-id><institution>Singapore Immunology Network (SIgN),</institution><institution>A*STAR, 8A Biomedical Grove,</institution></institution-wrap>Level 3 & 4 Immunos Building, Singapore, 138648 Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Level 3 & 4 Immunos Building, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Bing Ong, Chee" sort="Bing Ong, Chee" uniqKey="Bing Ong C" first="Chee" last="Bing Ong">Chee Bing Ong</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0620 9243</institution-id><institution-id institution-id-type="GRID">grid.418812.6</institution-id><institution>Histolopathology/Advanced Molecular Pathology Lab,</institution><institution>Institute of Molecular and Cell Biology (IMCB), A*STAR,</institution></institution-wrap>61 Biopolis Drive, Level 6 Proteos Building, Singapore, 138673 Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>61 Biopolis Drive, Level 6 Proteos Building, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Newell, Evan W" sort="Newell, Evan W" uniqKey="Newell E" first="Evan W." last="Newell">Evan W. Newell</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0637 0221</institution-id><institution-id institution-id-type="GRID">grid.185448.4</institution-id><institution>Singapore Immunology Network (SIgN),</institution><institution>A*STAR, 8A Biomedical Grove,</institution></institution-wrap>Level 3 & 4 Immunos Building, Singapore, 138648 Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Level 3 & 4 Immunos Building, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Goggi, Julian" sort="Goggi, Julian" uniqKey="Goggi J" first="Julian" last="Goggi">Julian Goggi</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0393 4167</institution-id><institution-id institution-id-type="GRID">grid.452254.0</institution-id><institution>Isotopic Molecular Imaging Laboratory,</institution><institution>Singapore Bioimaging Consortium (SBIC), A*STAR,</institution></institution-wrap>11 Biopolis Way, #02-02 Helios, Singapore, 138667 Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>11 Biopolis Way, #02-02 Helios, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Guan Ng, Lai" sort="Guan Ng, Lai" uniqKey="Guan Ng L" first="Lai" last="Guan Ng">Lai Guan Ng</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0637 0221</institution-id><institution-id institution-id-type="GRID">grid.185448.4</institution-id><institution>Singapore Immunology Network (SIgN),</institution><institution>A*STAR, 8A Biomedical Grove,</institution></institution-wrap>Level 3 & 4 Immunos Building, Singapore, 138648 Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Level 3 & 4 Immunos Building, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Renia, Laurent" sort="Renia, Laurent" uniqKey="Renia L" first="Laurent" last="Renia">Laurent Renia</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0637 0221</institution-id><institution-id institution-id-type="GRID">grid.185448.4</institution-id><institution>Singapore Immunology Network (SIgN),</institution><institution>A*STAR, 8A Biomedical Grove,</institution></institution-wrap>Level 3 & 4 Immunos Building, Singapore, 138648 Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Level 3 & 4 Immunos Building, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2180 6431</institution-id><institution-id institution-id-type="GRID">grid.4280.e</institution-id><institution>Department of Microbiology and Immunology, Yong Loo Lin School of Medicine,</institution><institution>National University of Singapore,</institution></institution-wrap>5 Science Drive 2 Blk MD4, Level 3, Singapore, 117545 Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>5 Science Drive 2 Blk MD4, Level 3, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Malaria-associated acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are life-threatening manifestations of severe malaria infections. The pathogenic mechanisms that lead to respiratory complications, such as vascular leakage, remain unclear. Here, we confirm that depleting CD8<sup>+</sup>T cells with anti-CD8β antibodies in C57BL/6 mice infected with <italic>P. berghei</italic> ANKA (PbA) prevent pulmonary vascular leakage. When we transfer activated parasite-specific CD8<sup>+</sup>T cells into PbA-infected TCRβ<sup>−/−</sup> mice (devoid of all T-cell populations), pulmonary vascular leakage recapitulates. Additionally, we demonstrate that PbA-infected erythrocyte accumulation leads to lung endothelial cell cross-presentation of parasite antigen to CD8<sup>+</sup>T cells in an IFNγ−dependent manner. In conclusion, pulmonary vascular damage in ALI is a consequence of IFNγ-activated lung endothelial cells capturing, processing, and cross-presenting malaria parasite antigen to specific CD8<sup>+</sup>T cells induced during infection. 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last="Claser">Carla Claser</name></noRegion><name sortKey="Balachander, Akhila" sort="Balachander, Akhila" uniqKey="Balachander A" first="Akhila" last="Balachander">Akhila Balachander</name><name sortKey="Becht, Etienne" sort="Becht, Etienne" uniqKey="Becht E" first="Etienne" last="Becht">Etienne Becht</name><name sortKey="Bing Ong, Chee" sort="Bing Ong, Chee" uniqKey="Bing Ong C" first="Chee" last="Bing Ong">Chee Bing Ong</name><name sortKey="Goggi, Julian" sort="Goggi, Julian" uniqKey="Goggi J" first="Julian" last="Goggi">Julian Goggi</name><name sortKey="Guan Ng, Lai" sort="Guan Ng, Lai" uniqKey="Guan Ng L" first="Lai" last="Guan Ng">Lai Guan Ng</name><name sortKey="Gunasegaran, Bavani" sort="Gunasegaran, Bavani" uniqKey="Gunasegaran B" first="Bavani" last="Gunasegaran">Bavani Gunasegaran</name><name sortKey="Hartimath, Siddesh V" sort="Hartimath, Siddesh V" uniqKey="Hartimath S" first="Siddesh V." last="Hartimath">Siddesh V. Hartimath</name><name sortKey="Lee, Audrey W Q" sort="Lee, Audrey W Q" uniqKey="Lee A" first="Audrey W. Q." last="Lee">Audrey W. Q. Lee</name><name sortKey="Newell, Evan W" sort="Newell, Evan W" uniqKey="Newell E" first="Evan W." last="Newell">Evan W. Newell</name><name sortKey="Nguee, Samantha Yee Teng" sort="Nguee, Samantha Yee Teng" uniqKey="Nguee S" first="Samantha Yee Teng" last="Nguee">Samantha Yee Teng Nguee</name><name sortKey="Nguee, Samantha Yee Teng" sort="Nguee, Samantha Yee Teng" uniqKey="Nguee S" first="Samantha Yee Teng" last="Nguee">Samantha Yee Teng Nguee</name><name sortKey="Renia, Laurent" sort="Renia, Laurent" uniqKey="Renia L" first="Laurent" last="Renia">Laurent Renia</name><name sortKey="Renia, Laurent" sort="Renia, Laurent" uniqKey="Renia L" first="Laurent" last="Renia">Laurent Renia</name><name sortKey="Theng Theng Ho, Jacqueline" sort="Theng Theng Ho, Jacqueline" uniqKey="Theng Theng Ho J" first="Jacqueline" last="Theng Theng Ho">Jacqueline Theng Theng Ho</name><name sortKey="Wu Howland, Shanshan" sort="Wu Howland, Shanshan" uniqKey="Wu Howland S" first="Shanshan" last="Wu Howland">Shanshan Wu Howland</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31534124" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |